Merendino R A, Arena A, Liberto M C, Iannello D, Bonina L, Mesiti M, Mastroeni P
Institute of Medical Microbiology, Messina University Medical School, Italy.
Cancer Detect Prev. 1988;12(1-6):73-80.
It has been repeatedly reported that several functions of mononuclear cells are impaired in patients affected by neoplasia. Moreover, inhibitory activity of serum and tumor extracts on macrophages have been described. In a previous study, we found a marked impairment of the intrinsic antiviral activity of macrophages derived from monocytes isolated from peripheral blood of patients with breast carcinoma or melanoma compared with that from blood of normal subjects. The aim of the present work was to study whether this impairment was due to circulating inhibitory factors. Macrophages were differentiated in vitro in sera from patients with neoplasia and in sera from healthy donors and then challenged with herpes simplex virus type 2 (HSV-2). Macrophages from normal subjects, incubated with sera from patients, were significantly impaired in their intrinsic antiviral activity. These results support the possibility that circulating inhibitory factors influence the functionality of mononuclear phagocytes in the tumor-bearing host.
反复有报道称，肿瘤患者的单核细胞的多种功能受损。此外，还描述了血清和肿瘤提取物对巨噬细胞的抑制活性。在先前的一项研究中，我们发现，与正常受试者血液中的单核细胞相比，乳腺癌或黑色素瘤患者外周血中分离出的单核细胞来源的巨噬细胞的固有抗病毒活性明显受损。本研究的目的是探讨这种损伤是否归因于循环抑制因子。将巨噬细胞在肿瘤患者血清和健康供体血清中进行体外分化，然后用2型单纯疱疹病毒（HSV-2）进行攻击。与患者血清一起孵育的正常受试者的巨噬细胞，其固有抗病毒活性显著受损。这些结果支持了循环抑制因子影响荷瘤宿主中单核吞噬细胞功能的可能性。
