Merendino R A, Arena A, Mancuso G, Zummo S, Chillemi S, Mesiti M, Bonina L
Institute of Microbiology, Medical School, University of Messina, Italy.
J Chemother. 1991 Feb;3(1):16-22. doi: 10.1080/1120009x.1991.11739057.
Macrophages from patients with breast cancer showed an impairment of their antiviral activity. The capability to hinder herpes simplex virus type 2 replication of macrophages from healthy donors and from patients with breast cancer was compared to the in-vitro treatment with Escherichia coli lipopolysaccharide (LPS). The LPS showed a dose-dependent effect on the different macrophage populations studied. Nevertheless, macrophages from healthy donors appeared to be more sensitive to LPS in comparison with macrophages from the patients under our observation. On these cells LPS treatment was not able to modify the antiviral property, when these macrophages were differentiated in autologous serum.
乳腺癌患者的巨噬细胞显示出抗病毒活性受损。将来自健康供体和乳腺癌患者的巨噬细胞阻碍单纯疱疹病毒2型复制的能力与用大肠杆菌脂多糖（LPS）进行的体外处理进行了比较。LPS对所研究的不同巨噬细胞群体显示出剂量依赖性效应。然而，与我们观察的患者的巨噬细胞相比，来自健康供体的巨噬细胞似乎对LPS更敏感。当这些巨噬细胞在自体血清中分化时，LPS处理无法改变其抗病毒特性。
