Basharova L A, Vetrilé L A, Evseev V A, Gromova E A, Bobkova N V, Plakzhinas L A, Fast L E
Laboratory of Pathophysiology of the Immune System, Academy of Medical Sciences of the USSR, Moscow.
Neurosci Behav Physiol. 1990 Mar-Apr;20(2):109-13. doi: 10.1007/BF01268129.
The influence of induction of antibodies to the neuromediator serotonin in the case of active immunization of animals with a conjugate serotonin-protein antigen on the distribution of biogenic amines in the brain and on behavioral responses was investigated in experiments on rats. It was shown that active immunization of rats with a serotonin-protein conjugate leads to a decrease in serotonin, its metabolite 5-hydroxyindole-3-acetic acid, as well as dopamine in certain brain structures. Against a background of induction of antibodies to serotonin, the horizontal motor activity of the animals is decreased.
