Goberman Alexander M, Blomgren Michael
Department of Communication Disorders, Bowling Green State University, Bowling Green, Ohio 43403-0149, USA.
J Voice. 2008 Mar;22(2):178-91. doi: 10.1016/j.jvoice.2006.07.006. Epub 2006 Sep 6.
After years of treatment with the medication levodopa, most individuals with Parkinson disease (PD) experience fluctuations in response to their medications. Although relatively consistent perceptual voice improvements have been documented to correspond with these fluctuations, consistent quantitative data to support this finding are lacking. This mismatch may have occurred because most of this phonation research has centered on long-term phonatory measures (ie, across speaking samples and prolonged vowel tasks). The current study examined short-term phonatory behavior in individuals with PD, specifically examining fundamental frequency (F0) at the offset and onset of phonation, before and after a voiceless consonant. The F0 analysis at phonatory offset supported the conclusion that individuals with PD have difficulty with the rapid offset of voicing, and that they are stopping vocal fold vibration primarily through vocal fold abduction (without adding tension). The F0 analysis at phonatory onset revealed that all groups use some laryngeal tension at the initiation of voicing. The tension was lowest for the PD participants who were in their OFF medication state, and it was highest for the age-matched control participants and the PD participants in their ON medication states.
在使用左旋多巴药物治疗多年后，大多数帕金森病（PD）患者对药物的反应会出现波动。尽管已有文献记载相对一致的嗓音感知改善与这些波动相对应，但缺乏支持这一发现的一致定量数据。这种不匹配可能是因为大多数此类发声研究都集中在长期发声测量上（即跨口语样本和延长元音任务）。当前研究考察了帕金森病患者的短期发声行为，特别研究了在无声辅音前后发声起始和结束时的基频（F0）。发声结束时的F0分析支持了以下结论：帕金森病患者在快速停止发声方面存在困难，并且他们主要通过声带外展（不增加张力）来停止声带振动。发声起始时的F0分析表明，所有组在发声开始时都会使用一些喉部张力。处于药物未起效状态的帕金森病参与者的张力最低，年龄匹配的对照参与者和处于药物起效状态的帕金森病参与者的张力最高。
