两种可被干扰素、双链RNA和病毒诱导的人类基因的染色体定位。
Chromosomal localization of two human genes inducible by interferons, double-stranded RNA, and viruses.
作者信息
Clauss I M, Wathelet M G, Szpirer J, Content J, Islam M Q, Levan G, Szpirer C, Huez G A
机构信息
Département de Biologie Moléculaire, Université Libre de Bruxelles, Rhode-St-Genèse, Belgium.
出版信息
Cytogenet Cell Genet. 1990;53(2-3):166-8. doi: 10.1159/000132920.
PMID:1695131
Abstract
Human IFI-15K and 6-16 genes are transcriptionally stimulated by interferons, double-stranded RNA, and viruses. By screening a cDNA library with oligodeoxynucleotide probes, we have isolated complete copies corresponding to these two genes. These cDNA clones allowed us to localize the IFI-15K and 6-16 genes on human chromosome 1 by somatic cell hybridization.
摘要
人类IFI-15K和6-16基因可被干扰素、双链RNA和病毒转录激活。通过用寡脱氧核苷酸探针筛选cDNA文库，我们分离出了与这两个基因相对应的完整拷贝。这些cDNA克隆使我们能够通过体细胞杂交将IFI-15K和6-16基因定位到人类1号染色体上。
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