乳酸乳球菌质粒pNP40的序列分析：一种应对环境危害的移动复制子。
Sequence analysis of the lactococcal plasmid pNP40: a mobile replicon for coping with environmental hazards.
作者信息
O'Driscoll Jonathan, Glynn Frances, Fitzgerald Gerald F, van Sinderen Douwe
机构信息
Department of Microbiology, University College Cork, Western Road, Cork, Ireland.
出版信息
J Bacteriol. 2006 Sep;188(18):6629-39. doi: 10.1128/JB.00672-06.
Abstract
The conjugative lactococcal plasmid pNP40, identified in Lactococcus lactis subsp. diacetylactis DRC3, possesses a potent complement of bacteriophage resistance systems, which has stimulated its application as a fitness-improving, food-grade genetic element for industrial starter cultures. The complete sequence of this plasmid allowed the mapping of previously known functions including replication, conjugation, bacteriocin resistance, heavy metal tolerance, and bacteriophage resistance. In addition, functions for cold shock adaptation and DNA damage repair were identified, further confirming pNP40's contribution to environmental stress protection. A plasmid cointegration event appears to have been part of the evolution of pNP40, resulting in a "stockpiling" of bacteriophage resistance systems.
摘要
在乳酸乳球菌亚种双乙酰乳酸乳球菌DRC3中鉴定出的接合型乳球菌质粒pNP40拥有一套强大的噬菌体抗性系统，这促使其作为一种改善适应性的食品级遗传元件应用于工业发酵剂培养物。该质粒的完整序列使得先前已知的功能得以定位，包括复制、接合、细菌素抗性、重金属耐受性和噬菌体抗性。此外，还鉴定出了冷休克适应和DNA损伤修复的功能，进一步证实了pNP40对环境应激保护的贡献。质粒共整合事件似乎是pNP40进化的一部分，导致了噬菌体抗性系统的“储备”。
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本文引用的文献
1
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Appl Environ Microbiol. 1996 Feb;62(2):676-9. doi: 10.1128/aem.62.2.676-679.1996.
2
Plasmids of lactococci - genetic accessories or genetic necessities?乳酸乳球菌质粒——基因附属物还是基因必需物？
FEMS Microbiol Rev. 2006 Mar;30(2):243-73. doi: 10.1111/j.1574-6976.2005.00011.x.
3
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Nucleic Acids Res. 2006 Jan 1;34(Database issue):D257-60. doi: 10.1093/nar/gkj079.
4
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Nucleic Acids Res. 2006 Jan 1;34(Database issue):D247-51. doi: 10.1093/nar/gkj149.
5
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Appl Environ Microbiol. 1993 Aug;59(8):2730-3. doi: 10.1128/aem.59.8.2730-2733.1993.
7
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