Kruse K, Jülicher F
Max-Planck-Institut für Physik komplexer Systeme, Nöthnitzerstr. 38, 01187, Dresden, Germany.
Eur Phys J E Soft Matter. 2006 Aug;20(4):459-65. doi: 10.1140/epje/i2006-10036-x. Epub 2006 Sep 5.
Motivated by the cytoskeleton of eukaryotic cells, we develop a general framework for describing the large-scale dynamics of an active filament network. In the cytoskeleton, active cross-links are formed by motor proteins that are able to induce relative motion between filaments. Starting from pair-wise interactions of filaments via such active processes, our framework is based on momentum conservation and an analysis of the momentum flux. This allows us to calculate the stresses in the filament network generated by the action of motor proteins. We derive effective theories for the filament dynamics which can be related to continuum theories of active polar gels. As an example, we discuss the stability of homogenous isotropic filament distributions in two spatial dimensions.
受真核细胞细胞骨架的启发,我们开发了一个用于描述活性细丝网络大规模动力学的通用框架。在细胞骨架中,活性交联由能够诱导细丝之间相对运动的运动蛋白形成。从细丝通过此类活性过程的成对相互作用出发,我们的框架基于动量守恒和动量通量分析。这使我们能够计算由运动蛋白的作用在细丝网络中产生的应力。我们推导了细丝动力学的有效理论,这些理论可以与活性极性凝胶的连续介质理论相关联。作为一个例子,我们讨论二维空间中均匀各向同性细丝分布的稳定性。