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巨细胞病毒和人类疱疹病毒6型与婴儿猝死综合征:一项原位杂交研究。

Cytomegalovirus and human herpesvirus-6 in sudden infant death syndrome: an in situ hybridization study.

作者信息

Coumbe A, Fox J D, Briggs M, Tedder R S, Berry C L

机构信息

Department of Morbid Anatomy, London Hospital Medical College, England.

出版信息

Pediatr Pathol. 1990;10(4):483-90. doi: 10.3109/15513819009067137.

DOI:10.3109/15513819009067137
PMID:1695370
Abstract

Thirty lung, spleen, and thymus sections and four lymph node sections from 40 sudden infant death syndrome (SIDS) cases were probed with biotinylated DNA probes specific for human herpesvirus-6 (HHV-6) and cytomegalovirus (CMV). Control material gave a strong, distinct signal with little or no background staining and no cross-reactivity. No staining was found with the SIDS material. We find no evidence to implicate an overwhelming infection by either virus in SIDS.

摘要

用针对人类疱疹病毒6型(HHV - 6)和巨细胞病毒(CMV)的生物素化DNA探针检测了40例婴儿猝死综合征(SIDS)病例的30个肺、脾和胸腺切片以及4个淋巴结切片。对照材料产生了强烈、清晰的信号,背景染色很少或没有,也没有交叉反应。在SIDS材料中未发现染色。我们没有发现证据表明这两种病毒中的任何一种在SIDS中存在压倒性感染。

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引用本文的文献

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J Clin Pathol. 2007 Oct;60(10):1173-7. doi: 10.1136/jcp.2007.048264. Epub 2007 Jun 1.
2
Detection of RNA viruses in sudden infant death (SID).婴儿猝死(SID)中RNA病毒的检测
Int J Legal Med. 2003 Aug;117(4):237-40. doi: 10.1007/s00414-003-0367-6. Epub 2003 May 14.
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Detection and significance of adenoviruses in cases of sudden infant death.
婴儿猝死病例中腺病毒的检测及意义
Virchows Arch. 1996 May;428(2):113-8. doi: 10.1007/BF00193939.