来自偶然分枝杆菌的新型链霉素抗性基因。
Novel streptomycin resistance gene from Mycobacterium fortuitum.
作者信息
Ramón-García Santiago, Otal Isabel, Martín Carlos, Gómez-Lus Rafael, Aínsa José A
机构信息
Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, C/ Domingo Miral s/n, 50009-Zaragoza, Spain.
出版信息
Antimicrob Agents Chemother. 2006 Nov;50(11):3920-2. doi: 10.1128/AAC.00223-06. Epub 2006 Sep 5.
Abstract
We have isolated the aph(3")-Ic gene, encoding an aminoglycoside 3"-O-phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.
摘要
我们从环境偶然分枝杆菌菌株的基因组文库中分离出了aph(3")-Ic基因，该基因编码一种氨基糖苷3"-O-磷酸转移酶[APH(3")-Ic]，筛选条件为对链霉素具有抗性。APH(3")-Ic使链霉素磷酸化并使其失活。在灰色链霉菌和质粒RSF1010中也描述过类似基因。它在一些偶然分枝杆菌临床分离株中也存在。
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