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Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on substance P-induced histamine release from rat peritoneal mast cells.

作者信息

McLeod J, Hayes N A, Foreman J C

机构信息

Department of Pharmacology, University College London, UK.

出版信息

Agents Actions. 1990 Apr;30(1-2):140-2. doi: 10.1007/BF01969021.

DOI:10.1007/BF01969021
PMID:1695435
Abstract

12-O-tetradecanoylphorbol-13-acetate (TPA, 1 to 30 ng/ml) produced a dose-related inhibition of substance P (SP)-induced histamine release from rat peritoneal mast cells. TPA itself induced some histamine release over this concentration range (maximum release about 20% of total). Maximum inhibition of SP-induced release by TPA required preincubation with TPA for at least 10 min. The inhibitory action of TPA was observed in the absence as well as in the presence of extracellular calcium (0.4 mM). Inhibition of diacylglycerol kinase by R 59022 or of diacylglycerol lipase by RHC 80267 reduced SP-induced histamine release. Oleolylacetylglycerol (OAG, 50 microM) inhibited histamine release induced by SP but was less potent than TPA. It is concluded that protein kinase C activation in rat peritoneal mast cells is associated with inhibition of SP-induced histamine release.

摘要

相似文献

1
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本文引用的文献

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Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267.大鼠和犬血小板磷脂酶A2及甘油二酯脂肪酶的相对活性。RHC 80267对甘油二酯脂肪酶的选择性抑制作用。
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Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells.蛋白激酶C与钙对大鼠腹膜肥大细胞组胺释放的协同作用。
Biochem Biophys Res Commun. 1984 Jun 15;121(2):573-8. doi: 10.1016/0006-291x(84)90220-1.
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Characteristics of the effect of phorbol ester on rat mast cells: interaction with anti-IgE.
Agents Actions. 1986 Apr;18(1-2):77-80. doi: 10.1007/BF01987988.
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