Halvorsen Jon Anders, Brevig Trine, Aas Torkild, Skar Anne Grete, Slevolden Ellen Margrethe, Moi Harald
Department of Dermatology, Ullevaal University Hospital, N-0407 Oslo, Norway.
Acta Derm Venereol. 2006;86(5):439-42. doi: 10.2340/00015555-0140.
Genital ulceration is an uncommon manifestation of primary Epstein-Barr virus (EBV) infection. We present here two cases of genital ulcers probably caused by EBV. The first case is a 12-year-old girl with a genital ulcer appearing before specific EBV serology could identify a primary infection. However, serology was positive 13 days after the ulcer appeared. Polymerase chain reaction for EBV was positive in the biopsy from the ulcer as well. The second case is an 18-year-old female in whom the specific EBV serology was positive 8 days after appearance of the ulcer. The ulcers in both cases healed after 21 days. We reviewed the literature and a total of 26 cases of EBV-associated genital ulcers in females are now published. Median age of the 26 cases is 14.5 years of whom only 6 reports previous sexual contact. Mean healing time for the ulcers is 18 days. Our two cases correspond well with clinical reports of 24 EBV-associated genital ulcers in the literature.
生殖器溃疡是原发性爱泼斯坦-巴尔病毒（EBV）感染的一种罕见表现。我们在此报告两例可能由EBV引起的生殖器溃疡病例。第一例是一名12岁女孩，在特定的EBV血清学检查能够确定原发性感染之前，其生殖器就出现了溃疡。然而，溃疡出现13天后血清学检查呈阳性。溃疡活检的EBV聚合酶链反应也呈阳性。第二例是一名18岁女性，溃疡出现8天后特定的EBV血清学检查呈阳性。两例患者的溃疡均在21天后愈合。我们查阅了文献，目前已发表了总共26例女性EBV相关生殖器溃疡病例。这26例患者的中位年龄为14.5岁，其中只有6例报告有过性接触。溃疡的平均愈合时间为18天。我们的两例病例与文献中24例EBV相关生殖器溃疡的临床报告非常吻合。
