Bleul Ulrich, Schwantag Silvia, Stocker Hans, Corboz Louis, Grimm Felix, Engels Monika, Borel Nicole, Lutz Hans, Schönmann Marietta, Kähn Wolfgang
Clinic of Reproductive Medicine, Vetsuisse-Faculty, University of Zurich, Switzerland.
J Vet Intern Med. 2006 Jul-Aug;20(4):1003-8. doi: 10.1892/0891-6640(2006)20[1003:fkscbd]2.0.co;2.
Goat kids with floppy kid syndrome have metabolic acidosis, muscle weakness, and depression but no dehydration.
D-Lactate is the major component of acidemia in goat kids with floppy kid syndrome.
Fifty-five goat kids with floppy kid syndrome (group F) and 35 clinically healthy goat kids (group C).
Clinical, biochemical, microbiologic, virologic, parasitologic, and pathologic examinations.
The animals in group F had a blood pH of 7.13 +/- 0.11 and a base excess of -17.8 +/- 3.8 mM, which were both lower than the values in the control animals (pH, 7.32 +/- 0.31; base excess, -0.1 +/- 2.7 mM; P < .001). Floppy kids had a significantly larger anion gap than healthy kids (31.2 +/- 3.7 versus 21.5 +/- 8.5 mM; P < .001). The concentration of L-lactate was lower in floppy kids than in healthy kids (0.67 +/- 0.49 versus 1.60 +/- 1.02 mM), but the concentration of D-lactate was higher in floppy kids (7.43 +/- 2.71 versus 0.26 +/- 0.24 mM; P < .001). Intravenous and oral administration of sodium bicarbonate in floppy kids resulted in a significant increase in blood pH and base excess and a decrease in the anion gap (P < .001). In addition, the concentration of L-lactate increased (P = .039).
Metabolic acidosis in goat kids with floppy kid syndrome is caused by an increase in the plasma concentration of D-lactate.
患有软羔综合征的山羊羔出现代谢性酸中毒、肌肉无力和精神沉郁，但无脱水症状。
D - 乳酸是患有软羔综合征的山羊羔酸血症的主要成分。
55只患有软羔综合征的山羊羔（F组）和35只临床健康的山羊羔（C组）。
进行临床、生化、微生物学、病毒学、寄生虫学和病理学检查。
F组动物的血液pH值为7.13±0.11，碱剩余为 - 17.8±3.8 mM，均低于对照动物的值（pH值，7.32±0.31；碱剩余， - 0.1±2.7 mM；P <.001）。患有软羔综合征的山羊羔的阴离子间隙明显大于健康山羊羔（31.2±3.7对21.5±8.5 mM；P <.001）。患有软羔综合征的山羊羔中L - 乳酸的浓度低于健康山羊羔（0.67±0.49对1.60±1.02 mM），但D - 乳酸的浓度在患有软羔综合征的山羊羔中较高（7.43±2.71对0.26±0.24 mM；P <.001）。对患有软羔综合征的山羊羔静脉内和口服给予碳酸氢钠导致血液pH值和碱剩余显著升高，阴离子间隙降低（P <.001）。此外，L - 乳酸的浓度增加（P = 0.039）。
患有软羔综合征的山羊羔的代谢性酸中毒是由血浆D - 乳酸浓度升高引起的。
