Effect of the association of nystatin with a tissue conditioner on its ultimate tensile strength.

PURPOSE

This study evaluated the ultimate tensile strength of a tissue conditioner without nystatin incorporation (GI-control group) and the same tissue conditioner modified by the addition of nystatin in two concentrations: GII-500,000 International Units (U) and GIII-1,000,000 U, in which each milligram of the medicament corresponded to 6079 U.

MATERIALS AND METHODS

Dumbbell-shaped specimens (N= 7) with a central cross-sectional area of 33 x 6 x 3 mm were produced for the three experimental groups. After polymerization following manufacturer's instructions, specimens were immersed in distilled water at 37 degrees C for either 24 hours or 7 days and then tested in tension in the MTS 810 at 40 mm/minute. Data were analyzed by two-way ANOVA followed by Tukey's test, at 95% level of confidence.

RESULTS

The means (force-grams (gf) +/- standard deviation) of the ultimate tensile strength were: GI-634.29 +/- 122.80; GII-561.92 +/- 133.56; and GIII-547.30 +/- 73.47 for 24-hour storage, and GI-536.68 +/- 54.71; GII-467.50 +/- 143.51; and GIII-500.62 +/- 159.76 for 7-day storage. There were no statistically significant differences among the three experimental groups (p > 0.05). The ultimate tensile strength means of all experimental groups after 7 days were significantly lower than those observed after 24 hours (p= 0.04).

CONCLUSIONS

The results of this study suggest that the addition of nystatin into the tissue conditioner investigated in concentrations below 1,000,000 U did not affect its ultimate tensile strength.