Khyshiktuev B S, Ivanov V N, Solov'eva N V, Zhits M Z
Lab Delo. 1990(5):18-22.
A method for assessing injury to the pulmonary surfactant system is suggested, based on studies of lipid peroxidation parameters in exhaled air condensate. Free-radical processes in pulmonary surfactants were examined in normal subjects and in patients with various forms of chronic nonspecific diseases of the respiratory organs. The findings evidence that a disease essentially intensifies lipid peroxidation in the alveolar lining, this being parallelled by reduced antiradical defense. Such an approach to studies of pulmonary surfactant system injuries is marked for its simplicity and atraumatism, this recommending it for mass clinical check-ups. Use of this method is promising as regards the disease prognosis and assessment of the treatment efficacy, as well as detection of subjects at high risk of developing bronchopulmonary diseases.
基于对呼出气冷凝物中脂质过氧化参数的研究，提出了一种评估肺表面活性物质系统损伤的方法。在正常受试者和患有各种形式慢性非特异性呼吸器官疾病的患者中，对肺表面活性物质中的自由基过程进行了研究。研究结果表明，疾病会显著加剧肺泡内衬中的脂质过氧化，同时抗自由基防御能力降低。这种研究肺表面活性物质系统损伤的方法具有简单和无创的特点，因此推荐用于大规模临床检查。该方法在疾病预后评估、治疗效果评估以及检测支气管肺部疾病高危人群方面具有应用前景。
