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[慢性支气管炎中的脂质过氧化过程]

[Lipid peroxidation processes in chronic bronchitis].

作者信息

Ignatova G L, Volchegorskiĭ I A, Volkova E G, Kazachkov E L, Kolesnikov O L

出版信息

Ter Arkh. 1998;70(3):36-7.

PMID:9575586
Abstract

AIM

Comparison of the levels of lipid peroxidation (LPO) products in condensate of the exhaled air (CEA) and in the biopsy samples from the inflammation focus.

MATERIALS AND METHODS

Extraction spectrophotometry was used to measure LPO products in CEA and biopsies from 30 males aged 30-60 years suffering from chronic bronchitis and 30 healthy controls of the same age.

RESULTS

There was activation of local accumulation of isopropanol-soluble LPO products in the bronchopulmonary system accompanied by lowered content of lipoperoxides and high antioxidant activity in CEA.

CONCLUSION

Chronic bronchitis is characterized by multidirectional shifts in LPO in the inflammation focus and CEA.

摘要

目的

比较呼出空气冷凝物(CEA)和炎症病灶活检样本中脂质过氧化(LPO)产物的水平。

材料与方法

采用萃取分光光度法测量30名年龄在30 - 60岁的慢性支气管炎男性患者的CEA和活检样本中的LPO产物,以及30名同龄健康对照者的CEA和活检样本中的LPO产物。

结果

支气管肺系统中异丙醇可溶性LPO产物的局部积累被激活,同时CEA中脂质过氧化物含量降低且抗氧化活性较高。

结论

慢性支气管炎的特征是炎症病灶和CEA中LPO发生多方向变化。

相似文献

1
[Lipid peroxidation processes in chronic bronchitis].[慢性支气管炎中的脂质过氧化过程]
Ter Arkh. 1998;70(3):36-7.
2
[The status of free radical processes in the pulmonary surfactant system in chronic bronchitis patients].
Vopr Med Khim. 1991 Jan-Feb;37(1):79-82.
3
The importance of exhaled air condensate in assessing the oxidant-antioxidant system in patients with chronic obstructive pulmonary disease.呼出气冷凝物在评估慢性阻塞性肺疾病患者氧化-抗氧化系统中的重要性。
Wiad Lek. 2003;56(1-2):19-23.
4
[Intensity of lipid peroxidation as an index of inflammation process in the acute phase of chronic bronchitis].[脂质过氧化强度作为慢性支气管炎急性期炎症过程的指标]
Biull Eksp Biol Med. 1997 Aug;124(8):202-4.
5
[Lipid peroxidation and the antioxidant activity of the sputum in chronic obstructive bronchitis].[慢性阻塞性支气管炎患者痰液中的脂质过氧化作用及抗氧化活性]
Lab Delo. 1991(10):21-3.
6
[A method for research on pulmonary surfactant in the vapor condensate of exhaled air].[一种研究呼出气体冷凝物中肺表面活性物质的方法]
Ter Arkh. 1992;64(10):105-7.
7
[The pathogenesis of a broncho-obstructive syndrome in patients with chronic bronchitis].[慢性支气管炎患者支气管阻塞综合征的发病机制]
Klin Med (Mosk). 1995;73(3):40-4.
8
[Indices of lipid peroxidation in the condensate of exhaled air--a simple and objective method of estimating injuries to the pulmonary surfactant system].[呼出空气冷凝物中脂质过氧化指标——一种评估肺表面活性物质系统损伤的简单客观方法]
Lab Delo. 1990(5):18-22.
9
[Chronic obstructive bronchitis: its pathogenetic aspects and the characteristics of its clinical course].[慢性阻塞性支气管炎:其发病机制及临床病程特点]
Ter Arkh. 1996;68(3):58-62.
10
[The level of biogenic amines in bronchi of patients with chronic obstructive bronchitis].[慢性阻塞性支气管炎患者支气管中生物胺的水平]
Klin Med (Mosk). 1991 May;69(5):60-3.

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