Wolfe Robert R
University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, TX 77550, USA.
Am J Clin Nutr. 2006 Sep;84(3):475-82. doi: 10.1093/ajcn/84.3.475.
Muscle plays a central role in whole-body protein metabolism by serving as the principal reservoir for amino acids to maintain protein synthesis in vital tissues and organs in the absence of amino acid absorption from the gut and by providing hepatic gluconeogenic precursors. Furthermore, altered muscle metabolism plays a key role in the genesis, and therefore the prevention, of many common pathologic conditions and chronic diseases. Nonetheless, the maintenance of adequate muscle mass, strength, and metabolic function has rarely, if ever, been targeted as a relevant endpoint of recommendations for dietary intake. It is therefore imperative that factors directly related to muscle mass, strength, and metabolic function be included in future studies designed to demonstrate optimal lifestyle behaviors throughout the life span, including physical activity and diet.
肌肉在全身蛋白质代谢中起着核心作用，它作为氨基酸的主要储存库，在肠道不吸收氨基酸的情况下维持重要组织和器官中的蛋白质合成，并提供肝脏糖异生的前体物质。此外，肌肉代谢的改变在许多常见病理状况和慢性疾病的发生以及预防中起着关键作用。然而，维持足够的肌肉质量、力量和代谢功能很少（如果有的话）被作为饮食摄入建议的相关终点目标。因此，在未来旨在证明整个生命周期最佳生活方式行为（包括体育活动和饮食）的研究中，必须纳入与肌肉质量、力量和代谢功能直接相关的因素。
