Kim Mijin, Kobori Toshiro
Institute of Food Research, National Agriculture and Food Research Organization, 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan.
Nutr Metab (Lond). 2025 Aug 4;22(1):88. doi: 10.1186/s12986-025-00978-1.
This study examined the associations between dynapenia, metabolic syndrome (MetS), nutrient intake, and physical activity.
We used data from a cross-sectional study that included middle-aged men and women (40-64 years old) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) between 2014 and 2017. Patients (n = 4700) were categorized into four groups based on diagnosis of dynapenia and MetS: dynapenic MetS (DM), dynapenia alone (D), MetS alone (M), and non-dynapenia and non-MetS (NDNM). Dynapenia was defined as the lowest tertile of the BMI-adjusted handgrip strength. MetS was defined as central obesity plus two or more of the following features: elevated fasting plasma glucose, blood pressure, or triglycerides, or reduced HDL cholesterol. Nutrient intake and physical activity were assessed via questionnaires.
In women, the DM group had a significantly lower intake of all nutrients except for total energy and carbohydrates compared to the NDNM group. In a model adjusted for age, osteoarthritis, and total energy intake, the DM group showed higher odds ratios (ORs) for not practicing resistance training (men: OR (95% confidence intervals (CI)) = 1.64 (1.22-2.20); women: OR (95% CI) = 2.26 (1.59-3.21)) and for engaging in physical activities below 600 metabolic equivalents of tasks per week (men: OR (95% CI) = 1.36 (1.05-1.78); women: OR (95% CI) = 1.29 (1.02-1.63)) than the NDNM group. The women in the DM group had significantly higher OR for leisure-related moderate (OR (95% CI) = 2.00 (1.49-2.68)) and vigorous (OR (95% CI) = 1.76 (1.10-2.82)) physical inactivity than in the NDNM group.
This study showed that the combination of dynapenia and MetS was associated with poor nutrient intake in women and low physical activity in both sexes. These findings provide a foundation for developing intervention strategies to address dynapenia and MetS.
本研究调查了肌肉减少症、代谢综合征（MetS）、营养摄入与身体活动之间的关联。
我们使用了一项横断面研究的数据，该研究纳入了2014年至2017年期间参加韩国国民健康与营养检查调查（KNHANES）的中年男性和女性（40 - 64岁）。患者（n = 4700）根据肌肉减少症和MetS的诊断分为四组：肌肉减少性MetS（DM）组、单纯肌肉减少症（D）组、单纯MetS（M）组以及非肌肉减少症和非MetS（NDNM）组。肌肉减少症定义为体重指数（BMI）调整后的握力处于最低三分位数。MetS定义为中心性肥胖加上以下两项或更多特征：空腹血糖升高、血压升高、甘油三酯升高或高密度脂蛋白胆固醇降低。通过问卷调查评估营养摄入和身体活动情况。
在女性中，与NDNM组相比，DM组除总能量和碳水化合物外的所有营养素摄入量均显著较低。在对年龄、骨关节炎和总能量摄入进行调整的模型中，DM组不进行抗阻训练的比值比（OR）较高（男性：OR（95%置信区间（CI））= 1.64（1.22 - 2.20）；女性：OR（95% CI）= 2.26（1.59 - 3.21）），且每周进行低于600代谢当量任务的身体活动的OR也较高（男性：OR（95% CI）= 1.36（1.05 - 1.78）；女性：OR（95% CI）= 1.29（1.02 - 1.63）），均高于NDNM组。DM组女性在休闲相关的中度（OR（95% CI）= 2.00（1.49 - 2.68））和剧烈（OR（95% CI）= 1.76（1.10 - 2.82））身体不活动方面的OR显著高于NDNM组。
本研究表明，肌肉减少症和MetS的组合与女性营养摄入不良以及两性身体活动不足有关。这些发现为制定应对肌肉减少症和MetS的干预策略提供了基础。
