Bouchard Maryse, Mergler Donna, Baldwin Mary, Panisset Michel, Roels Harry A
CINBIOSE, Université du Québec à Montréal, Institut des Sciences de l'environnement, CINBIOSE (SB-1983), C.P. 8888, Succ. Centre-Ville, Montréal, Québec H3C 3P8, Canada.
Neurotoxicology. 2007 Mar;28(2):290-7. doi: 10.1016/j.neuro.2006.08.002. Epub 2006 Aug 12.
Psychiatric manifestations have been reported in cases of manganism, and mood disorders are often observed in manganese (Mn) exposed workers. We examined neuropsychiatric symptoms among formerly Mn-exposed workers 14 years after cessation of exposure.
A study was conducted in 1990 among workers from a ferro- and silico-Mn plant and unexposed working men referents from the same region in South-West Quebec. At follow-up in 2004, 77 former Mn-workers and 81 referents agreed to participate and responded to a neuropsychiatric symptom checklist, the Brief Symptom Inventory (BSI); scores were transformed into T-scores based on a normative population. Cumulated exposure indices (CEI) were computed for each former Mn-worker. Linear and logistic regression analyses were used.
Mean T-scores were significantly higher among former Mn-workers than referents on scales of Depression and Anxiety. Mean T-scores of psychological distress increased with the CEI tertiles, with significant associations for the scales Somatization, Depression, Anxiety and Hostility. Former Mn-workers in the two highest tertiles of CEI showed a higher risk for T-scores >or=63 for Hostility (OR, 7.5; 95% CI, 1.5-38.9), Depression (OR, 2.6; 95% CI, 1.1-8.4) and Anxiety (OR, 3.0; 95% CI, 1.1-8.4).
These results suggest that past exposure to Mn may have lasting consequences on neuropsychiatric symptoms.
已有报道称锰中毒病例会出现精神症状，且在接触锰（Mn）的工人中常观察到情绪障碍。我们对停止接触锰14年后的既往接触锰工人的神经精神症状进行了检查。
1990年对一家锰铁和硅锰工厂的工人以及来自魁北克西南部同一地区未接触锰的在职男性对照者进行了一项研究。在2004年的随访中，77名 former Mn-workers 和81名对照者同意参与并对一份神经精神症状清单即简明症状量表（BSI）做出回应；根据正常人群将分数转换为T分数。为每位 former Mn-worker 计算累积接触指数（CEI）。使用线性和逻辑回归分析。
former Mn-workers 在抑郁和焦虑量表上的平均T分数显著高于对照者。心理困扰的平均T分数随CEI三分位数增加，在躯体化、抑郁、焦虑和敌对量表上有显著关联。CEI处于两个最高三分位数的former Mn-workers 在敌对（OR，7.5；95%CI，1.5 - 38.9）、抑郁（OR，2.6；95%CI，1.1 - 8.4）和焦虑（OR，3.0；95%CI，1.1 - 8.4）方面T分数≥63的风险更高。
这些结果表明过去接触锰可能对神经精神症状有持久影响。
文中“former Mn-workers”未明确给出准确中文表述，暂保留英文。
