Chinn D R, Myers R K, Matthews J A
J Am Vet Med Assoc. 1985 Apr 15;186(8):806-9.
A 3 1/2-year-old dog with extensive tumor metastases to the lungs was found to have neutrophilic leukocytosis termed a leukemoid reaction. The term leukemoid reaction describes an absolute increase in the blood leukocyte concentration without regard to a predominant cell type or to the degree of cell immaturity. These types of reactions are extremely difficult to differentiate from leukemia. Leukemoid reactions can be acute or chronic and they may have an infectious, inflammatory, toxic, or neoplastic origin. Those reactions attributable to neoplasia have been documented in medical literature, but the mechanism causing the granulocytosis has not always been clearly understood. A granulopoietin capable of stimulating a leukemoid reaction may be elaborated by certain types of tumors, tumors with extensive metastasis, or tumors involving the lungs, liver, or stomach.
一只3岁半的狗被发现肺部有广泛的肿瘤转移，伴有中性粒细胞增多，称为类白血病反应。类白血病反应是指血液中白细胞浓度绝对增加，而不考虑主要细胞类型或细胞不成熟程度。这类反应极难与白血病区分开来。类白血病反应可分为急性或慢性，其病因可能是感染、炎症、中毒或肿瘤。医学文献中已记载了由肿瘤引起的这类反应，但导致粒细胞增多的机制并不总是完全清楚。某些类型的肿瘤、有广泛转移的肿瘤或累及肺、肝或胃的肿瘤可能会产生一种能够刺激类白血病反应的粒细胞生成素。
