Furukawa Noboru, Miyamura Nobuhiro, Nishida Kenro, Motoshima Hiroyuki, Taketa Kayo, Araki Eiichi
Department of Metabolic Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
Diabetes Res Clin Pract. 2007 Mar;75(3):366-7. doi: 10.1016/j.diabres.2006.07.005. Epub 2006 Sep 11.
The insulin autoimmune syndrome is characterized as producing polyclonal or monoclonal anti-insulin autoantibodies in a patient with no previous history of exposure to exogenous insulin. The patient is 44-year-old Japanese woman and she had symptoms of hypoglycaemia without exposure to exogenous insulin. The patient was considered to have IAS because high titre of anti-insulin autoantibodies (96-98%: bound/total) were found in her serum. Her HLA DR beta1 DNA sequences analysis revealed that she has the DRB1()0406 and DRB1()0901. Our patient have been taken alpha lipoic acid (ALA) before onset. SH group compounds are known to play an important role in the pathogenesis of IAS, and ALA contains SH. From these data, we propose the possibility of the correlation between pathogenesis of IAS and ALA, and it will be important to pay attention for ALA as a cause of hypoglycemia in such cases.
胰岛素自身免疫综合征的特征是在既往无外源性胰岛素暴露史的患者体内产生多克隆或单克隆抗胰岛素自身抗体。该患者为一名44岁的日本女性，在未接触外源性胰岛素的情况下出现低血糖症状。该患者被认为患有IAS，因为在其血清中发现了高滴度的抗胰岛素自身抗体（96 - 98%：结合/总量）。她的HLA DR beta1 DNA序列分析显示她具有DRB1()0406和DRB1()0901。我们的患者在发病前曾服用α硫辛酸（ALA）。已知含巯基（SH）的化合物在IAS的发病机制中起重要作用，而ALA含有SH。基于这些数据，我们提出了IAS发病机制与ALA之间存在相关性的可能性，并且在这类病例中关注ALA作为低血糖原因将很重要。
