Picker Susanne Maria, Radojska Stela Marinova, Gathof Birgit Sybille
Transfusion Medicine, University of Cologne, Cologne, Germany.
Transfusion. 2006 Sep;46(9):1601-8. doi: 10.1111/j.1537-2995.2006.00928.x.
To improve productivity of automated platelet (PLT) collection, the industry has introduced new instruments or modifications to existing equipment.
With the same 8 donors for double (DDC) and triple-dose PLT collection (TDC), the Baxter Amicus (AM), the Haemonetics MCS Plus (MCS+), and the Gambro Trima Accel (TA) were evaluated focusing on yield, duration, and citrate donor load. Target endpoints were set at 5.5 x 10(11) to 6.0 x 10(11) PLTs (DDC) and 7.5 x 10(11) to 8.0 x 10(11) PLTs (TDC) in up to 100 and 120 minutes' donation time, respectively.
TA was the most efficient system (74.5 +/- 3.9%) with significant differences from AM (71.1 +/- 3.9%; p = 0.028) and MCS+ (64.0 +/- 7.7%; p = 0.002). TA had advantages over AM for collection rate (10.9 x 10(9) +/- 2.2 x 10(9) vs. 10.1 x 10(9) +/- 1.5 x 10(9) PLTs/min; p = 0.382), whole blood processed (3928 +/- 611 mL vs. 4219 +/- 727 mL; p = 0.382), and time to obtain an established standard dose (TSD 2.5(EU), 30.2 +/- 5.6 vs. 37.7 +/- 5.5 min; TSD 3.5(US), 42.2 +/- 7.8 min vs. 52.7 +/- 7.7 min; p = 0.015), whereas AM was slightly superior in PLT yield (2.81 x 10(11) +/- 0.21 x 10(11) vs. 2.76 x 10(11) +/- 0.31 x 10(11)/unit; p = 0.645). Owing to the lowest draw (42.3 +/- 3.2 mL/min; p < 0.001) and collection rates (6.0 x 10(11) +/- 1.5 x 10(11)/min; p = 0.021), MCS+ was the slowest significantly (p < 0.001) but compensated with fewer citrate reactions owing to lower citrate infusion rates (0.78 +/- 0.11 mL/min/L; p = 0.028).
High-dose plateletpheresis was performed efficiently and safely with all three instruments. AM had advantages in PLT yield, and MCS+, in donor comfort. TA was the fastest in obtaining an established standard dose and, because of this advantage, the machine with the highest practical impact in routine use.
为提高自动血小板（PLT）采集的效率，该行业推出了新仪器或对现有设备进行了改进。
使用相同的8名供体进行双倍剂量（DDC）和三倍剂量PLT采集（TDC），对百特阿米库斯（AM）、海莫奈特MCS Plus（MCS+）和甘布罗Trima Accel（TA）进行评估，重点关注产量、持续时间和枸橼酸盐供体负荷。目标终点分别设定为在最长100分钟和120分钟的献血时间内采集到5.5×10¹¹至6.0×10¹¹个PLT（DDC）和7.5×10¹¹至8.0×10¹¹个PLT（TDC）。
TA是效率最高的系统（74.5±3.9%），与AM（71.1±3.9%；p = 0.028）和MCS+（64.0±7.7%；p = 0.002）有显著差异。TA在采集速率（10.9×10⁹±2.2×¹⁰⁹个PLT/分钟对10.1×10⁹±1.5×10⁹个PLT/分钟；p = 0.382）、处理的全血量（3928±611毫升对4219±727毫升；p = .382）以及达到既定标准剂量的时间（TSD 2.5（欧盟），30.2±5.6分钟对37.7±5.5分钟；TSD 3.5（美国），42.2±7.8分钟对52.7±7.分钟；p = 0.015）方面优于AM，而AM在PLT产量上略占优势（2.81×10¹¹±0.21×10¹¹个/单位对2.76×10¹¹±0.31×10¹¹个/单位；p = 0.645）。由于最低采血速率（42.3±3.2毫升/分钟；p < 0.001）和采集速率（6.0×10¹¹±1.5×10¹¹个/分钟；p = 0.021），MCS+明显是最慢的（p < 0.001），但由于较低的枸橼酸盐输注速率（0.78±0.11毫升/分钟/升；p = 0.028），枸橼酸盐反应较少。
使用这三种仪器均能高效、安全地进行高剂量血小板单采。AM在PLT产量方面具有优势，MCS+在供体舒适度方面具有优势。TA在达到既定标准剂量方面最快，由于这一优势，在常规使用中具有最高的实际影响力。
Zotero 插件