Chellaiya Gayathiri K, Murugesan M, Nayanar Sangeetha K
1Department of Transfusion Medicine, Malabar Cancer Centre, Thalassery, Kerala India.
2Department of Oncopathology, Malabar Cancer Centre, Thalassery, Kerala India.
Indian J Hematol Blood Transfus. 2020 Jan;36(1):135-140. doi: 10.1007/s12288-019-01163-0. Epub 2019 Jul 27.
With improvements in apheresis collection, platelet additive solution (PAS) is steadily replacing plasma as the storage medium in single donor platelets (SDP). Concentrating platelets in SDP with one-third of plasma and two-thirds of PAS is referred as Concentrated-SDP (C-SDP). We studied the influence of donor hematocrit (Hct) in C-SDP procedures. A retrospective study, consisting of 124 and 95 plateletpheresis donors in MCS+ and Trima respectively. We compared two apheresis equipments MCS+ and Trima with regard to donor hematocrit on procedural parameters such as collection efficiency (CE), collection rate (CR), yield per hour (Y/H), yield per litre (Y/L) and percentage blood volume processed (%BV) during C-SDP procedures. Donors were categorized into two groups with Group A (Hct ≤ 46%) and Group B (Hct > 46%) based on mean baseline Hct of the study population. Among the 219 procedures, the overall CE was significantly higher for Trima over MCS+ equipment (77 vs 56, < 0.001). However, there was no difference in procedural outcomes like CE, Y/L, Y/H, CR with MCS+ or Trima equipment between groups. %BV processed had a negative correlation with hematocrit in MCS+ ( = - 0.305, = 0.001) and no difference was observed with Trima equipment. Donor Hct influences C-SDP collection only in processed blood volume with MCS+ equipment. Trima had statistically better performance over MCS+ equipments in all procedural parameters during C-SDP procedures. The data will guide apheresis centre to choose equipments based on donor characteristics.
随着单采技术的改进，血小板添加剂溶液（PAS）正逐渐取代血浆，成为单采血小板（SDP）的储存介质。将SDP中的血小板与三分之一的血浆和三分之二的PAS浓缩在一起，称为浓缩SDP（C-SDP）。我们研究了C-SDP程序中供体血细胞比容（Hct）的影响。这是一项回顾性研究，分别纳入了124例使用MCS+设备和95例使用Trima设备的血小板单采供体。我们比较了两种单采设备MCS+和Trima在C-SDP程序中的供体血细胞比容对采集效率（CE）、采集率（CR）、每小时产量（Y/H）、每升产量（Y/L）和处理血容量百分比（%BV）等程序参数的影响。根据研究人群的平均基线Hct，将供体分为两组，A组（Hct≤46%）和B组（Hct>46%）。在219例程序中，Trima设备的总体CE显著高于MCS+设备（77对56，<0.001）。然而，两组之间使用MCS+或Trima设备时，CE、Y/L、Y/H、CR等程序结果没有差异。MCS+设备中处理的%BV与血细胞比容呈负相关（r=-0.305，P=0.001），而Trima设备未观察到差异。供体Hct仅在使用MCS+设备处理的血容量方面影响C-SDP采集。在C-SDP程序中，Trima在所有程序参数方面的表现均在统计学上优于MCS+设备。这些数据将指导单采中心根据供体特征选择设备。
