Taylor N F, Dodd K J, Prasad D, Denisenko S
Musculoskeletal Research Centre, School of Physiotherapy, Faculty of Health Sciences, La Trobe University, Victoria, 3086, Australia.
Disabil Rehabil. 2006 Sep 30;28(18):1119-26. doi: 10.1080/09638280500531834.
This study aimed to determine if participation in a progressive resistance exercise (PRE) programme can: (1) increase the ability to generate maximal muscle force, (2) increase muscle endurance, (3) increase functional activity, and (4) improve overall psychological function of people with multiple sclerosis (MS).
A pre-post single group research design with a 4-week baseline familiarisation phase was used. Nine people (mean age 45.6 years, SD 10.7) with MS attended a gymnasium three times over 4 weeks for familiarization. Participants then completed a twice-weekly 10-week PRE programme, with two sets of 10 - 12 repetitions of each exercise. Outcome measures of muscle strength (1RM for arms and legs), muscle endurance (repetitions at half 1RM), walking speed, the 2-min walk test (2MWT), a timed stairs test, and the impact of MS on physical and psychological function were taken at weeks 2, 4, and 14.
Participants attended 94.3% (SD 8.2%) of the training sessions, with no adverse events. After accounting for baseline stability, significant improvements (P < 0.05) were found in arm strength (14.4%), leg endurance (170.9%), fast walking speed (6.1%), and there was a trend for increased distance in the 2MWT (P = 0.06). The perceived impact of MS on physical function was reduced (P = 0.02).
Adults with MS benefited from a PRE programme by improving muscle performance and physical activities, without adverse events. These findings suggest that PRE may be a feasible and useful fitness alternative for people with mild to moderate disability due to MS.
本研究旨在确定参与渐进性抗阻训练（PRE）计划是否能够：（1）提高产生最大肌肉力量的能力；（2）增强肌肉耐力；（3）增加功能活动；（4）改善多发性硬化症（MS）患者的整体心理功能。
采用单组前后测研究设计，有一个为期4周的基线熟悉阶段。9名MS患者（平均年龄45.6岁，标准差10.7）在4周内到健身房进行了3次熟悉训练。参与者随后完成了一项为期10周的PRE计划，每周两次，每次练习两组，每组10 - 12次重复。在第2、4和14周测量肌肉力量（手臂和腿部的1RM）、肌肉耐力（1RM的一半重量下的重复次数）、步行速度、2分钟步行测试（2MWT）、定时楼梯测试以及MS对身体和心理功能的影响等结果指标。
参与者参加了94.3%（标准差8.2%）的训练课程，未发生不良事件。在考虑基线稳定性后，发现手臂力量（提高14.4%）、腿部耐力（提高170.9%）、快走速度（提高6.1%）有显著改善（P < 0.05），并且2MWT中的行走距离有增加趋势（P = 0.06）。MS对身体功能的感知影响有所降低（P = 0.02）。
患有MS的成年人通过参与PRE计划，肌肉性能和身体活动得到改善，且无不良事件。这些发现表明，PRE可能是MS导致轻度至中度残疾患者可行且有用的健身选择。
