Szczerbal I, Stefaniak T, Dubiel A, Siembieda J, Nizanski W, Switonski M
Department of Genetics and Animal Breeding, August Cieszkowski Agricultural University of Poznan, Wolynska 33, 60-637 Poznan, Poland.
Vet Pathol. 2006 Sep;43(5):789-92. doi: 10.1354/vp.43-5-789.
We report here on a case of a Holstein-Friesian male calf with the congenital total absence of thoracic limbs (amelia). Cytogenetic study showed a high rate of chromosome instability, represented by chromosome or chromatid breaks and gaps in 46% of the analyzed metaphase spreads. Moreover, 12% of the spreads appeared to be polypolid. The number of micronuclei also was significantly higher when compared to control animals. This paper discusses the association between chromosome instability and limb malformation.
我们在此报告一例荷斯坦 - 弗里生公牛犊先天性胸肢完全缺失（无肢畸形）的病例。细胞遗传学研究显示染色体不稳定性发生率很高，在46%的分析中期分裂相中表现为染色体或染色单体断裂及裂隙。此外，12%的分裂相似乎是多倍体。与对照动物相比，微核数量也显著更高。本文讨论了染色体不稳定性与肢体畸形之间的关联。
