Di Berardino D, Iannuzzi L, Fregola A, Matassino D
Vet Rec. 1983 Apr 30;112(18):429-32. doi: 10.1136/vr.112.18.429.
High rates of structural chromosome aberrations were associated with increased yields of sister chromatid exchanges (SCE) in metaphase chromosomes of a new born female calf affected by a congenital malformation. The frequency of abnormal cells was 25 per cent in the abnormal calf, 8 per cent in its dam and 3 per cent in a group of four healthy cows. Chromatid and chromosome breaks were the most frequent types of chromosome aberration found in the malformed calf; centric fusions, chromosome fragments and deletions were much less common. The mean rate of SCE/cell in the malformed calf was nearly twice that of the control and the difference was statistically significant. Possible factors involved in the occurrence of such a malformation are discussed.
在一头患有先天性畸形的新生雌性小牛的中期染色体中，高频率的结构染色体畸变与姐妹染色单体交换（SCE）产量增加有关。异常小牛中异常细胞的频率为25%，其母亲中为8%，一组四头健康母牛中为3%。染色单体和染色体断裂是在畸形小牛中发现的最常见的染色体畸变类型；着丝粒融合、染色体片段和缺失则不太常见。畸形小牛中每个细胞的SCE平均率几乎是对照组的两倍，且差异具有统计学意义。文中讨论了这种畸形发生可能涉及的因素。
