Nasal air sampling for measuring inhaled wheat allergen in bakeries with and without facemask use.
作者信息
Renström Anne, Mattsson Marie-Louise, Blidberg Kristin, Doekes Gert, Bogdanovic Jelena, Tovey Euan
机构信息
Lung and Allergy Research, Institute of Environmental Medicine, Karolinska Institutet (KI), Stockholm, Sweden.
出版信息
J Occup Environ Med. 2006 Sep;48(9):948-54. doi: 10.1097/01.jom.0000232533.04238.3e.
OBJECTIVE
Occupational asthma caused by flour is common in bakers. We applied novel intranasal air samplers (INAS) to assess wheat allergen exposure and evaluate respiratory protection in bakeries.
METHODS
Two models of INAS (INAS-M1 and INAS-M2) were compared with simultaneous personal air sampling of inhalable dust, both with and without facemasks. Wheat allergen levels were measured using a sensitive sandwich enzyme immunoassay. Allergenic particles were immunostained for microscopic visualization.
RESULTS
Personal air sampling correlated well with INAS-M1 (r = 0.89) and INAS-M2 (r = 0.75). INAS-M2 collected particles more effectively than INAS-M1. Facemasks reduced inhalation of wheat allergen by 96% and 93% measured using INAS-M1 and INAS-M2, respectively.
CONCLUSIONS
Nasal air sampling can complement personal air sampling to measure short-term exposure and evaluate respiratory protection. To prevent baker's asthma, facemasks may be an effective solution in addition to improving workplaces.
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