Gayzik F Scott, Bostrom Ola, Ortenwall Per, Duma Stefan M, Stitzel Joel D
Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.
Annu Proc Assoc Adv Automot Med. 2006;50:13-32.
A carotid artery dissection begins as a tear or defect of the intimal lining of the artery, and can lead to luminal occlusion and ultimately cerebral ischemia. Our aim is to conduct an organ level validation of a finite element model of the carotid artery using an experiment designed to elicit internal layer failure within fluid-filled carotid artery samples. A 2.4-kg beveled guillotine is dropped from three heights (0.3, 0.5 and 0.7 m) onto fluid-filled porcine carotid arteries and resulting damage is recorded. These events are modeled using finite element analysis. Stress, strain and strain rate are correlated to experimental outcome. Internal layer damage is reported in half of the experiments, with damage occurring with 100% frequency at a drop height of 0.7 m. Simulations of this experiment result in maximum principal stress and strain values of 1.43 MPa and 46.2% respectively. The strain level predicted by the model for this impact scenario approaches the strain to intimal failure level for porcine arteries found in the literature. The results of this study represent an important step in validating this finite element carotid artery model at the organ level.
颈动脉夹层始于动脉内膜衬里的撕裂或缺损，并可导致管腔闭塞，最终引发脑缺血。我们的目标是通过一项旨在引发充液颈动脉样本内层失效的实验，对颈动脉有限元模型进行器官水平的验证。将一个2.4千克的斜面断头台从三个高度（0.3米、0.5米和0.7米）掉落至充液的猪颈动脉上，并记录由此产生的损伤。使用有限元分析对这些事件进行建模。应力、应变和应变率与实验结果相关。在一半的实验中报告了内层损伤，在0.7米的掉落高度时损伤出现的频率为100%。该实验的模拟结果分别得出最大主应力和应变值为1.43兆帕和46.2%。该模型针对此冲击场景预测的应变水平接近文献中发现的猪动脉内膜失效应变水平。本研究结果是在器官水平验证此有限元颈动脉模型的重要一步。
