Intapan Pewpan M, Prasongdee Thidarat K, Laummaunwai Porntip, Sawanyawisuth Kittisak, Singthong Saree, Maleewong Wanchai
Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Am J Trop Med Hyg. 2006 Sep;75(3):563-4.
An in vitro test for the detection of ivermectin sensitivity of Strongyloides stercoralis in human clinical specimens was developed. The test has a simple procedure that combines parasite culture with a drug assay. It is based on the principle of the drug effect on larval development test, combined with a modified coproculture using the filter paper culture technique. This does not require parasite isolation, and drug sensitivity can be shown in relationship to the dose. This test can be applied in field surveys for anthelmintic sensitivity and for appropriate drug rotation strategies when drug resistance occurs.
开发了一种用于检测人体临床标本中粪类圆线虫对伊维菌素敏感性的体外试验。该试验程序简单，将寄生虫培养与药物测定相结合。它基于药物对幼虫发育试验的作用原理，并结合使用滤纸培养技术的改良粪便培养法。这不需要分离寄生虫，并且可以显示药物敏感性与剂量的关系。该试验可应用于驱虫药敏感性的现场调查，以及在出现耐药性时制定适当的药物轮换策略。
