Tsou V Marc, Baker Robert, Book Linda, Hammo Abdel-Hai, Soffer Elaine F, Wang Wenjin, Comer Gail M
Children's Hospital of The King's Daughter, Norfolk, VA, USA
Clin Pediatr (Phila). 2006 Oct;45(8):741-9. doi: 10.1177/0009922806292792.
An age-appropriate questionnaire (GASP-Q) was used to assess the frequency and severity of the gastroesophageal reflux disease (GERD) symptoms: abdominal/belly pain, chest pain/heartburn, pain after eating, nausea, burping/belching, vomiting/regurgitation, choking when eating, and difficulty swallowing, in adolescents age 12 to 16 years. The primary objective was to compare the mean composite symptom score (CSS) at week 8 with baseline after treatment with 20 or 40 mg of pantoprazole. Statistically significant (p < 0.001) improvement in CSS occurred in both groups. Safety was comparable between the 2 groups. Pantoprazole was safe, well tolerated, and effective in reducing symptoms of GERD in adolescents.
采用一份适合该年龄段的问卷（GASP-Q）来评估12至16岁青少年胃食管反流病（GERD）症状的频率和严重程度，这些症状包括：腹痛、胸痛/烧心、进食后疼痛、恶心、打嗝、呕吐/反流、进食时噎食和吞咽困难。主要目的是比较使用20毫克或40毫克泮托拉唑治疗8周后的平均综合症状评分（CSS）与基线水平。两组的CSS均有统计学显著改善（p < 0.001）。两组之间的安全性相当。泮托拉唑在减轻青少年GERD症状方面安全、耐受性良好且有效。
