特异性血小板活化因子拮抗剂CV-6209对不同致炎剂所致大鼠足爪水肿影响的比较研究

Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents.

作者信息

Merlos M, Gómez L A, Vericat L, García-Rafanell J, Forn J

机构信息

Research Center, J. Uriach & Cía, S.A., Barcelona, Spain.

出版信息

Pharmacology. 1990;40(4):211-7. doi: 10.1159/000138661.

DOI:10.1159/000138661

PMID:1697076

Abstract

Comparative effects of CV-6209, a potent and specific platelet activating factor (PAF) antagonist, on PAF-acether-, carrageenin-, histamine-, serotonin-, compound 48/80-, dextran-, zymosan A- and arachidonic acid-induced rat paw edema were investigated. CV-6209 has proven to be effective in PAF-induced edema, but it also showed a significant activity in other models of paw edema, except those induced by zymosan A and arachidonic acid. Other drugs tested, namely indometacin, mepyramine, methysergide and nordihydroguaiaretic acid showed a more selective inhibitory profile. These results suggest an important role of PAF in the inflammatory process caused by intraplantar injection of different phlogogenes in the rat paw.

摘要

研究了强效特异性血小板活化因子（PAF）拮抗剂CV - 6209对PAF - 乙酰醚、角叉菜胶、组胺、5 - 羟色胺、化合物48/80、右旋糖酐、酵母聚糖A和花生四烯酸诱导的大鼠足爪水肿的比较作用。CV - 6209已被证明对PAF诱导的水肿有效，但它在其他足爪水肿模型中也显示出显著活性，酵母聚糖A和花生四烯酸诱导的水肿模型除外。所测试的其他药物，即吲哚美辛、美吡拉敏、甲基麦角新碱和去甲二氢愈创木酸显示出更具选择性的抑制作用。这些结果表明PAF在大鼠足爪内注射不同致炎剂引起的炎症过程中起重要作用。