Kim Sung Hee, Hyun Sun Hee, Choung Se Young
Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
Biofactors. 2006;26(3):209-19. doi: 10.1002/biof.5520260306.
Both Cinnamomi cassiae and Rhodiola rosea extracts are used as anti-diabetic folk medicines. Recently, increased oxidative stress was shown to play an important role in the etiology and pathogenesis of diabetes mellitus and its complications. This study was designed to examine the effects of Cinnamomi cassiae and Rhodiola rosea extracts on blood glucose, lipid peroxidation, the level of reduced glutathione and its related enzymes (glutathione reductase, glutathione S-transferase), and the activity of the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the liver of db/db mice. Diabetic C57BL/Ks db/db mice were used as experimental models. Mice were divided into control (n=10), Cinnamomi cassiae (200 mg/kg/day, n=10), and Rhodiola rosea (200 mg/kg/day, n=10) treated groups for 12 weeks of treatment. These type II diabetic mice were used to investigate the effects of Cinnamomi cassiae and Rhodiola rosea on blood glucose, reduced glutathione, glutathione reductase, glutathione S-transferase, glutathione peroxidase, lipid peroxidation, catalase and superoxide dismutase. Cinnamomi cassiae and Rhodiola rosea extracts significantly decreased on blood glucose, increased levels of reduced glutathione and the activities of glutathione reductase, glutathione S-transferase, glutathione peroxidase, catalase and superoxide dismutase in the liver. Extract treatment also significantly decreased lipid peroxidation. Cinnamomi cassiae and Rhodiola rosea extracts may be effective for correcting hyperglycemia and preventing diabetic complications.
肉桂提取物和红景天提取物都被用作抗糖尿病民间药物。最近，研究表明氧化应激增加在糖尿病及其并发症的病因和发病机制中起重要作用。本研究旨在检测肉桂提取物和红景天提取物对db/db小鼠肝脏血糖、脂质过氧化、还原型谷胱甘肽水平及其相关酶（谷胱甘肽还原酶、谷胱甘肽S转移酶）以及抗氧化酶（过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶）活性的影响。将糖尿病C57BL/Ks db/db小鼠用作实验模型。将小鼠分为对照组（n = 10）、肉桂提取物治疗组（200 mg/kg/天，n = 10）和红景天提取物治疗组（200 mg/kg/天，n = 10），进行为期12周的治疗。使用这些II型糖尿病小鼠来研究肉桂提取物和红景天提取物对血糖、还原型谷胱甘肽、谷胱甘肽还原酶、谷胱甘肽S转移酶、谷胱甘肽过氧化物酶、脂质过氧化、过氧化氢酶和超氧化物歧化酶的影响。肉桂提取物和红景天提取物可显著降低血糖，提高肝脏中还原型谷胱甘肽水平以及谷胱甘肽还原酶、谷胱甘肽S转移酶、谷胱甘肽过氧化物酶、过氧化氢酶和超氧化物歧化酶的活性。提取物治疗还可显著降低脂质过氧化。肉桂提取物和红景天提取物可能对纠正高血糖和预防糖尿病并发症有效。
