一种与肾综合征出血热相关的新型普马拉病毒基因型的特征分析。

Characterization of a new Puumala virus genotype associated with hemorrhagic fever with renal syndrome.

作者信息

Bahr Udo, Zeier Martin, Muranyi Walter

机构信息

Klinikum der Universität Heidelberg, Sektion Nephrologie Im Neuenheimer Feld 162, D-69120 Heidelberg, Federal Republic of Germany.

出版信息

Virus Genes. 2006 Oct;33(2):229-34. doi: 10.1007/s11262-005-0061-5.

DOI:10.1007/s11262-005-0061-5

PMID:16972039

Abstract

Hantavirus serotype Puumala (PUUV) is the etiologic agent of Nephropathia epidemica (NE), a mild variant of Hemorrhagic Fever with Renal Syndrome (HFRS) in Europe, with lethality rates up to 1% among human patients. The serotype PUUV is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. We describe a new, geographically and phylogenetically well-defined pathogenic PUUV sublineage in Southwest Germany (strain Heidelberg/hu) originated from an HFRS patient. The genetic analysis of PUUV strain Heidelberg/hu may contribute in future to better diagnostics, the development of vaccines, and the understanding of the factors that determine hantavirus pathogenesis.

摘要

汉坦病毒普马拉血清型（PUUV）是流行性肾病（NE）的病原体，NE是欧洲肾综合征出血热（HFRS）的一种轻型变体，在人类患者中的致死率高达1%。PUUV血清型由众多地理分布受限的毒株组成，形成了大量的系统发育谱系、亚谱系、变体和簇。我们描述了一种新的、在地理和系统发育上定义明确的致病性PUUV亚谱系，它来自德国西南部的一名HFRS患者（海德堡/hu毒株）。对PUUV海德堡/hu毒株的基因分析未来可能有助于改进诊断、疫苗研发以及理解决定汉坦病毒发病机制的因素。