Queloz Pierre-Alain, Thadikkaran Lynne, Crettaz David, Rossier Joel S, Barelli Stefano, Tissot Jean-Daniel
Service régional vaudois de transfusion sanguine, Lausanne, Switzerland.
Proteomics. 2006 Oct;6(20):5605-14. doi: 10.1002/pmic.200600179.
Limited number of important discoveries have greatly contributed to the progresses achieved in the blood transfusion; ABO histo-blood groups, citrate as anticoagulant, fractionation of plasma proteins, plastic bags and apheresis machines. Three major types of blood products are transfused to patients: red cell concentrates, platelet concentrates and fresh frozen plasma. Several parameters of these products change during storage process and they have been well studied over the years. However, several aspects have completely been ignored; in particular those related to peptide and protein changes. This review presents what has been done using proteomic tools and the potentials of proteomics for transfusion medicine.
少数重要的发现极大地推动了输血领域所取得的进展；ABO 组织血型、柠檬酸盐作为抗凝剂、血浆蛋白的分离、塑料袋和血液成分分离机。有三种主要类型的血液制品被输注给患者：红细胞浓缩物、血小板浓缩物和新鲜冰冻血浆。这些制品的几个参数在储存过程中会发生变化，并且多年来已经得到了充分研究。然而，有几个方面完全被忽视了；特别是那些与肽和蛋白质变化相关的方面。这篇综述介绍了利用蛋白质组学工具所做的工作以及蛋白质组学在输血医学中的潜力。
