Saga Kitamura Rodrigo O, Romoff Paulete, Young Maria Cláudia M, Kato Massuo J, Lago João Henrique G
Faculdade de Ciências Biológicas, Exatas e Experimentais, Universidade Presbiteriana Mackenzie, 01302-970 São Paulo - SP, Brazil.
Phytochemistry. 2006 Nov;67(21):2398-402. doi: 10.1016/j.phytochem.2006.08.007. Epub 2006 Sep 14.
Chromatographic separation of the CH2Cl2 extract from leaves of Peperomia serpens yielded two chromenes [5-hydroxy-8-(3',7'-dimethylocta-2',6'-dienyl)-2,2,7-trimethyl-2H-1-chromene (1) and 5-hydroxy-8-(3'-methyl-2'-butenyl)-2,2,7-trimethyl-2H-1-chromene-6-carboxylic acid (2)], besides the known chromene [methyl 5-hydroxy-2,2,7-trimethyl-2H-1-chromene-6-carboxylate (3)] and the flavonoid, dihydrooroxylin (4). Their structural elucidation were achieved by spectroscopic analyses. The antifungal activities of the CH2Cl2 extract and the isolated chromenes were measured bioautographically against Cladosporium cladosporioides and C. sphaerospermum, when it was found that the crude extract showed higher activity as compared to the pure compounds.
对豆瓣绿叶片的二氯甲烷提取物进行色谱分离，除了已知的色烯[5-羟基-2,2,7-三甲基-2H-1-色烯-6-羧酸甲酯（3）]和类黄酮二氢奥洛西宁（4）外，还得到了两种色烯[5-羟基-8-(3',7'-二甲基辛-2',6'-二烯基)-2,2,7-三甲基-2H-1-色烯（1）和5-羟基-8-(3'-甲基-2'-丁烯基)-2,2,7-三甲基-2H-1-色烯-6-羧酸（2）]。通过光谱分析确定了它们的结构。采用生物自显影法测定了二氯甲烷提取物和分离得到的色烯对枝孢菌和球孢枝孢菌的抗真菌活性，结果发现粗提物的活性高于纯化合物。
