从叶片中分离两种新化合物和其他成分及其可溶性环氧化物水解酶活性研究。

Isolation of Two New Compounds and Other Constituents from Leaves of and Study of Their Soluble Epoxide Hydrolase Activities.

机构信息

College of Pharmacy, Chungnam National University, Daejeon 34134, Korea.

Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea.

出版信息

Molecules. 2019 Jan 30;24(3):489. doi: 10.3390/molecules24030489.

DOI:10.3390/molecules24030489

PMID:30704047

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6384562/

Abstract

Two new phenolic glucosides, pipercroside A and B ( and ), along with 10 known compounds were isolated from the leaves of Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II () showed inhibitory activity with an IC value of 58.5 µM.

摘要

从 Ruiz & Pav 的叶子中分离得到两种新的酚糖苷胡椒酸甲酯 A 和 B（1 和 2）以及 10 种已知化合物。通过广泛的光谱分析，包括 1D 和 2D NMR 实验和 HR-ESI-MS 分析，并与以前报道的数据进行比较，阐明了它们的化学结构。所有分离得到的化合物均进行了可溶性环氧化物水解酶（sEH）抑制活性评估。其中，erigeside II（3）表现出抑制活性，IC 值为 58.5 µM。