反复给予胸腺因子血清（FTS）对衰老加速小鼠（SAM）中与衰老相关的生化变化的影响。

Effects of repeated administrations of facteur thymique sérique (FTS) on biochemical changes related to aging in senescence-accelerated mouse (SAM).

作者信息

Zhao X H, Awaya A, Kobayashi H, Ohnuki T, Tokumitsu Y, Nomura Y

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

出版信息

Jpn J Pharmacol. 1990 Jul;53(3):311-9. doi: 10.1254/jjp.53.311.

DOI:10.1254/jjp.53.311

PMID:1697347

Abstract

Superoxide dismutase (SOD) activity,malondialdehyde (MDA) content and monoamine oxidase B (MAO-B) activity were measured in the brain, liver and kidney of a normal aging strain (R/1) and an accelerating aging strain (P/8) senescence-accelerated mice (SAM) at 9-10 months of age, and the effects of facteur thymique sérique (FTS) were examined. The activity of Cu,Zn-SOD in the kidney and MAO-B in the liver was significantly low and high in SAM-P/8 compared to SAM-R/1. FTS enhanced the activity of Mn-SOD and Cu,Zn-SOD in the kidney of SAM-P/8 and Cu,Zn-SOD activity in the brain of both SAM-P/8 and SAM-R/1. It decreased the activity of MAO-B in the liver and the contents of malondialdehyde (MDA) in the brain and kidney of SAM-P/8. Thus, FTS affects the biochemical factors related to senescence in SAM-P/8, a particular senescent animal model, and may thus possibly be effective as an anti-senescent medicine.

摘要

在9至10月龄的正常衰老品系（R/1）和加速衰老品系（P/8）的衰老加速小鼠（SAM）的脑、肝和肾中测量超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量和单胺氧化酶B（MAO-B）活性，并检测胸腺因子血清（FTS）的作用。与SAM-R/1相比，SAM-P/8肾中Cu,Zn-SOD活性显著降低，肝中MAO-B活性显著升高。FTS增强了SAM-P/8肾中Mn-SOD和Cu,Zn-SOD的活性，以及SAM-P/8和SAM-R/1脑内Cu,Zn-SOD的活性。它降低了SAM-P/8肝中MAO-B的活性以及脑和肾中丙二醛（MDA）的含量。因此，FTS影响特定衰老动物模型SAM-P/8中与衰老相关的生化因子，因而可能作为一种抗衰老药物有效。