结合特定配体的RNA分子的体外筛选。
In vitro selection of RNA molecules that bind specific ligands.
作者信息
Ellington A D, Szostak J W
机构信息
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
出版信息
Nature. 1990 Aug 30;346(6287):818-22. doi: 10.1038/346818a0.
DOI:10.1038/346818a0
PMID:1697402
Abstract
Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.
摘要
已从随机序列RNA分子群体中分离出能特异性结合多种有机染料的RNA分子亚群。在10¹⁰个随机序列RNA分子中，大约有一个会以某种方式折叠，从而为小分子配体创造出一个特异性结合位点。
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