Ellington A D, Szostak J W
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
Nature. 1990 Aug 30;346(6287):818-22. doi: 10.1038/346818a0.
Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 10(10) random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.
已从随机序列RNA分子群体中分离出能特异性结合多种有机染料的RNA分子亚群。在10¹⁰个随机序列RNA分子中，大约有一个会以某种方式折叠，从而为小分子配体创造出一个特异性结合位点。
