Nakazawa Hideyuki, Ito Toshiro, Makishima Hideki, Misawa Noriko, Okiyama Wataru, Uehara Takeshi, Hidaka Eiko, Kiyosawa Kendo, Ishida Fumihiro
Department of Internal Medicine/Hematology, Shinshu University School of Medicine, Matsumoto, Nagano.
Intern Med. 2006;45(16):975-80. doi: 10.2169/internalmedicine.45.1699. Epub 2006 Sep 15.
Adenovirus is one of the major causes of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation for hematological malignancy. Fulminant hepatic failure is a rare manifestation of post-transplant complication with adenovirus. Extremely high mortality and aggressiveness of the clinical course have been posing clinical challenges for the diagnosis as well as for the treatment. Here, we report a case with disseminated adenovirus disease presenting with fulminant hepatic failure after bone marrow transplantation for acute lymphoblastic leukemia.
腺病毒是血液系统恶性肿瘤异基因造血干细胞移植后非复发发病率和死亡率的主要原因之一。暴发性肝衰竭是移植后腺病毒并发症的一种罕见表现。临床病程的极高死亡率和侵袭性给诊断和治疗带来了临床挑战。在此，我们报告一例急性淋巴细胞白血病骨髓移植后出现暴发性肝衰竭的播散性腺病毒病病例。
