Terasako Kiriko, Oshima Kumi, Wada Hidenori, Ishihara Yuko, Kawamura Koji, Sakamoto Kana, Ashizawa Masahiro, Sato Miki, Machishima Tomohito, Nakasone Hideki, Kimura Shun-ichi, Kikuchi Misato, Okuda Shinya, Kako Shinichi, Yamazaki Rie, Takeuchi Kengo, Nishida Junji, Yamada Shigeki, Tanaka Osamu, Kanda Yoshinobu
Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan.
Intern Med. 2012;51(4):405-11. doi: 10.2169/internalmedicine.51.6432. Epub 2012 Feb 15.
Disseminated adenovirus disease after allogeneic hematopoietic stem cell transplantation (HSCT) is lethal in most cases, especially when it develops as fulminant hepatic failure. We encountered a patient who developed fulminant hepatic failure caused by adenovirus infection. She did not show manifestations of graft-versus-host disease and the results of serum tests for viral infection were all negative. Abdominal computed tomography (CT) findings were consistent with peliosis hepatitis. She died of fulminant hepatic failure, however, and pathological examinations of the liver specimen obtained after her death revealed adenovirus infection. In this report, we review the clinical characteristics and imaging findings of fulminant hepatic failure caused by adenovirus infection.
异基因造血干细胞移植（HSCT）后播散性腺病毒病在大多数情况下是致命的，尤其是当它发展为暴发性肝衰竭时。我们遇到一名因腺病毒感染而发生暴发性肝衰竭的患者。她没有出现移植物抗宿主病的表现，病毒感染血清检测结果均为阴性。腹部计算机断层扫描（CT）结果与紫癜性肝炎相符。然而，她死于暴发性肝衰竭，死后获得的肝脏标本病理检查显示存在腺病毒感染。在本报告中，我们回顾了腺病毒感染所致暴发性肝衰竭的临床特征和影像学表现。
