异基因骨髓移植患者中腺病毒所致的致死性暴发性肝衰竭
Fatal fulminant hepatic failure from adenovirus in allogeneic bone marrow transplant patients.
作者信息
Vyas Jatin M, Marasco Wayne A
机构信息
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Case Rep Infect Dis. 2012;2012:463569. doi: 10.1155/2012/463569. Epub 2012 Aug 15.
Abstract
We report two cases of fatal hepatic failure in patients who received matched unrelated bone marrow transplantation. Both patients presented with high fevers, abnormal liver functions tests, and hypodense lesions in the liver by CT scan. Histologic examination of postmortem liver samples demonstrated extensive necrosis, and immunohistochemistry was positive for adenovirus.
摘要
我们报告了两例接受匹配的无关供者骨髓移植患者发生致命性肝衰竭的病例。两名患者均出现高热、肝功能检查异常，且CT扫描显示肝脏有低密度病变。尸检肝脏样本的组织学检查显示广泛坏死，免疫组化检测腺病毒呈阳性。
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