Maeda Y, Mabuchi E, Koyama T, Kano M, Arita N
Department of Neurosurgery, Osaka Rosai Hospital.
No Shinkei Geka. 1990 Jul;18(7):675-80.
The occurrence sites of intracranial primary germ cell tumors are most often the pineal and suprasellar regions. The histological type observed most frequently in these tumors is germinoma. Cases of embryonal carcinoma arising in the basal ganglia are rarely reported. To our knowledge, only 4 such cases have been previously reported in the literature. A case of an embryonal carcinoma arising in the basal ganglia is reported. A 17-year-old boy was admitted to our hospital on July 30, 1988 because of headache and vomiting, and a right hemiparesis. On admission, physical inspection showed no abnormalities and neurological examination revealed obtunded consciousness, a right central facial paresis and a right hemiparesis with Hoffman and Babinski reflexes. Noncontrast CT scan showed a large mass of low-to slightly high-density in the region of the left basal ganglia accompanied with midline shift and ventricular dilatation. Enhancement of the lesion was made by contrast CT scan. It was not homogeneous. Cerebral angiogram displayed a contralateral shift and an unrolling of the anterior cerebral artery, a lateral stretch of middle cerebral artery, a downward stretch of anterior choroidal artery and a tumor stain fed by the Heubner artery. On August 3, left frontotemporal craniotomy was performed. The tumor was totally removed in a piecemeal manner using microsurgical techniques. Histopathological diagnosis was mixed-type of germ cell tumor comprising embryonal carcinoma and teratoma. Postoperative CT scan showed complete disappearance of the tumor. A course of radiation of 4950 rads and two courses of a combination chemotherapy with cis-platinum, vinblastine and bleomycin were given within 3 months after the operation.(ABSTRACT TRUNCATED AT 250 WORDS)
颅内原发性生殖细胞肿瘤最常发生的部位是松果体区和鞍上区。这些肿瘤中最常观察到的组织学类型是生殖细胞瘤。基底节区发生胚胎癌的病例鲜有报道。据我们所知,此前文献中仅报道过4例此类病例。本文报道1例基底节区发生的胚胎癌。一名17岁男孩于1988年7月30日因头痛、呕吐及右侧偏瘫入院。入院时,体格检查未见异常,神经系统检查发现意识迟钝、右侧中枢性面瘫及右侧偏瘫,伴有霍夫曼征和巴宾斯基征。非增强CT扫描显示左侧基底节区有一大块低密度至略高密度肿块,伴有中线移位和脑室扩张。增强CT扫描显示病变有强化,且不均匀。脑血管造影显示对侧移位及大脑前动脉迂曲、大脑中动脉向外侧伸展、脉络膜前动脉向下伸展以及由Heubner动脉供血的肿瘤染色。8月3日,行左侧额颞开颅手术。采用显微外科技术将肿瘤分块完全切除。组织病理学诊断为混合性生殖细胞肿瘤,包括胚胎癌和畸胎瘤。术后CT扫描显示肿瘤完全消失。术后3个月内给予4950拉德的放疗疗程以及两疗程顺铂、长春碱和博来霉素联合化疗。(摘要截短于250字)