Jiang Tao, Yang Hongchao, Wang Junmei, Du Jiang, Zhang Wenhui, Shao Qiang, Li Chunde
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
Beijing Neurosurgical Institute, Capital Medical University Beijing, China.
Int J Clin Exp Pathol. 2017 Nov 1;10(11):10700-10710. eCollection 2017.
Embryonal carcinoma is a rare malignant brain tumor and stands for 5% of all intracranial germ cell tumors. Embryonal carcinoma occurs mainly in the posterior third ventricle and pineal region area. Preoperative imaging examination, blood serum and cerebrospinal fluid level of AFP and HCG can support the diagnosis. Subtotal to total removal with good preservation of the important structures can be achieved in this tumor resection. Embryonal carcinoma has poor prognosis result. Postoperative radiotherapy and adjuvant chemotherapy may increase the survival rate, but due to the malignant characteristics of the tumor the 5 years survival rate remains low. We presented two cases of embryonal carcinoma in children. Subtotal resection was achieved in these two patients; patient who had had postoperative radiotherapy and adjuvant chemotherapy had longer survival time than patient who had had surgery alone.
胚胎癌是一种罕见的恶性脑肿瘤，占所有颅内生殖细胞肿瘤的5%。胚胎癌主要发生在第三脑室后部和松果体区域。术前影像学检查、血清和脑脊液中AFP和HCG水平可辅助诊断。该肿瘤切除术中可实现次全切除至全切除，并很好地保留重要结构。胚胎癌预后较差。术后放疗和辅助化疗可能提高生存率，但由于肿瘤的恶性特征，5年生存率仍然较低。我们报告了两例儿童胚胎癌病例。这两名患者均实现了次全切除；接受术后放疗和辅助化疗的患者比仅接受手术的患者生存时间更长。
