Radbruch Andreas, Muehlinghaus Gwendolin, Luger Elke O, Inamine Ayako, Smith Kenneth G C, Dörner Thomas, Hiepe Falk
Deutsches Rheuma-Forschungszentrum Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
Nat Rev Immunol. 2006 Oct;6(10):741-50. doi: 10.1038/nri1886. Epub 2006 Sep 15.
Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-lived end-stage products of B-cell differentiation that deserve little interest. This view is changing, however, because we now know that plasma cells can survive for long periods in the appropriate survival niches and that they are an independent cellular component of immunological memory. Studies of the biology of plasma cells reveal a mechanism of intriguing simplicity and elegance that focuses memory provided by plasma cells on recently encountered pathogens while minimizing the 'fading' of memory for pathogens encountered in the distant past. This mechanism is based on competition for survival niches between newly generated plasmablasts and older plasma cells.
浆细胞提供体液免疫。传统上，它们主要被视为B细胞分化的短期终末产物，不太受关注。然而，这种观点正在改变，因为我们现在知道浆细胞可以在合适的存活微环境中长时间存活，并且它们是免疫记忆的独立细胞成分。对浆细胞生物学的研究揭示了一种简单而优雅的机制，该机制将浆细胞提供的记忆集中于最近遇到的病原体，同时尽量减少对很久以前遇到的病原体记忆的“消退”。这种机制基于新生成的浆母细胞与较老的浆细胞之间对存活微环境的竞争。
