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1
Multiple infusions of human intravenous immunoglobulin in chimpanzees do not lead to immune elimination.在黑猩猩中多次输注人静脉注射免疫球蛋白不会导致免疫清除。
Clin Exp Immunol. 1990 Sep;81(3):454-8. doi: 10.1111/j.1365-2249.1990.tb05355.x.
2
Total serum protein, serum protein fractions and serum immunoglobulins in colostrum-fed and colostrum-deprived calves.初乳喂养和未喂初乳犊牛的血清总蛋白、血清蛋白组分及血清免疫球蛋白
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4
Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes.前房内及静脉注射可溶性抗原后的独特体液免疫反应。对分泌IgG2的B淋巴细胞进行主动抑制的证据。
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IgA immunity in HIV type 1-infected chimpanzees. I. Systemic immunity.1型人类免疫缺陷病毒感染黑猩猩中的IgA免疫。I. 全身免疫。
AIDS Res Hum Retroviruses. 1997 Oct 10;13(15):1263-72. doi: 10.1089/aid.1997.13.1263.
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7
Modification of the Fc region of a primatized IgG antibody to human CD4 retains its ability to modulate CD4 receptors but does not deplete CD4(+) T cells in chimpanzees.将人源化IgG抗体针对人CD4的Fc区域进行修饰后，其仍保留调节CD4受体的能力，但不会使黑猩猩体内的CD4(+) T细胞耗竭。
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IgE and IgG subclass regulation by IL-4 and IFN-gamma in human helminth infections. Assessment by B cell precursor frequencies.人蠕虫感染中白细胞介素-4和干扰素-γ对免疫球蛋白E和免疫球蛋白G亚类的调节。通过B细胞前体频率进行评估。
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Induction of immunological tolerance to rabbit gamma G in adult animals.成年动物对兔γ球蛋白免疫耐受性的诱导。
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Serum immunoglobulins and immunoglobulin G subclasses in cystic fibrosis related to the clinical state of the patient.囊性纤维化患者血清免疫球蛋白及免疫球蛋白G亚类与患者临床状态的关系。
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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One-step purification of mouse monoclonal antibodies from ascitic fluid by DEAE Affi-Gel blue chromatography.通过DEAE亲和蓝胶色谱法从腹水原液中一步纯化小鼠单克隆抗体。
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Immunoregulatory abnormalities in mucocutaneous lymph node syndrome.皮肤黏膜淋巴结综合征中的免疫调节异常。
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Fc fragment activation of T lymphocytes. I. Fc fragments trigger Lyt 1+23- T lymphocytes to release a helper T cell-replacing activity.T淋巴细胞的Fc片段激活。I. Fc片段触发Lyt 1+23- T淋巴细胞释放一种替代辅助性T细胞的活性物质。
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T lymphocyte surface antigens in primates.灵长类动物的T淋巴细胞表面抗原
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Safety and efficacy of a monomeric, functionally intact intravenous IgG preparation in patients with primary immunodeficiency syndromes.一种单体、功能完整的静脉注射免疫球蛋白制剂在原发性免疫缺陷综合征患者中的安全性和有效性。
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Alteration of T cell subsets and immunoglobulin synthesis in vitro during high dose gamma-globulin therapy in patients with idiopathic thrombocytopenic purpura.特发性血小板减少性紫癜患者大剂量γ球蛋白治疗期间体外T细胞亚群及免疫球蛋白合成的改变
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Human T cell antigen expression by primate T cells.灵长类T细胞对人类T细胞抗原的表达。
Science. 1982 Jan 15;215(4530):298-300. doi: 10.1126/science.6171885.
9
Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy.丙种球蛋白治疗诱导的商陆有丝分裂原刺激的T和B淋巴细胞反应功能障碍。
J Clin Invest. 1981 Mar;67(3):867-77. doi: 10.1172/jci110104.
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Metabolic properties of IgG subclasses in man.人类IgG亚类的代谢特性
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在黑猩猩中多次输注人静脉注射免疫球蛋白不会导致免疫清除。

Multiple infusions of human intravenous immunoglobulin in chimpanzees do not lead to immune elimination.

作者信息

Leibl H, Wolf H M, Eder G, Mannhalter J W, Eibl M M

机构信息

Immuno, Vienna, Austria.

出版信息

Clin Exp Immunol. 1990 Sep;81(3):454-8. doi: 10.1111/j.1365-2249.1990.tb05355.x.

DOI:10.1111/j.1365-2249.1990.tb05355.x
PMID:1697798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534983/
Abstract

Administration of human i.v. immunoglobulins was shown to lead to a permanent increase in IgG1 and IgG2 levels in chimpanzees. Half-lives of human IgG1 and IgG2 in chimpanzees were comparable to those found in humans, and no signs of immune elimination were observed. Furthermore, long-term treatment of chimpanzees had no effect on the percentage of immunoregulatory T cells (CD2+, CD4+ and CD8+ T cells) as determined by FACS analysis. In addition, serum IgM levels in chimpanzees were found to be comparable to those in humans, whereas the chimpanzees' IgG levels are slightly elevated due to higher concentrations of IgG2 and, in particular, IgG4.

摘要

静脉注射人免疫球蛋白已被证明会导致黑猩猩体内IgG1和IgG2水平持续升高。人IgG1和IgG2在黑猩猩体内的半衰期与在人类体内的半衰期相当，且未观察到免疫清除的迹象。此外，通过流式细胞术分析确定，对黑猩猩进行长期治疗对免疫调节性T细胞（CD2 +、CD4 +和CD8 + T细胞）的百分比没有影响。另外，发现黑猩猩的血清IgM水平与人类相当，而由于IgG2尤其是IgG4浓度较高，黑猩猩的IgG水平略有升高。