在黑猩猩中多次输注人静脉注射免疫球蛋白不会导致免疫清除。
Multiple infusions of human intravenous immunoglobulin in chimpanzees do not lead to immune elimination.
作者信息
Leibl H, Wolf H M, Eder G, Mannhalter J W, Eibl M M
机构信息
Immuno, Vienna, Austria.
出版信息
Clin Exp Immunol. 1990 Sep;81(3):454-8. doi: 10.1111/j.1365-2249.1990.tb05355.x.
Administration of human i.v. immunoglobulins was shown to lead to a permanent increase in IgG1 and IgG2 levels in chimpanzees. Half-lives of human IgG1 and IgG2 in chimpanzees were comparable to those found in humans, and no signs of immune elimination were observed. Furthermore, long-term treatment of chimpanzees had no effect on the percentage of immunoregulatory T cells (CD2+, CD4+ and CD8+ T cells) as determined by FACS analysis. In addition, serum IgM levels in chimpanzees were found to be comparable to those in humans, whereas the chimpanzees' IgG levels are slightly elevated due to higher concentrations of IgG2 and, in particular, IgG4.
静脉注射人免疫球蛋白已被证明会导致黑猩猩体内IgG1和IgG2水平持续升高。人IgG1和IgG2在黑猩猩体内的半衰期与在人类体内的半衰期相当，且未观察到免疫清除的迹象。此外，通过流式细胞术分析确定，对黑猩猩进行长期治疗对免疫调节性T细胞（CD2 +、CD4 +和CD8 + T细胞）的百分比没有影响。另外，发现黑猩猩的血清IgM水平与人类相当，而由于IgG2尤其是IgG4浓度较高，黑猩猩的IgG水平略有升高。
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