Hodson M E, Morris L, Batten J C
Department of Cystic Fibrosis, Brompton Hospital, London.
Eur Respir J. 1988 Aug;1(8):701-5.
Levels of serum immunoglobulins and immunoglobulin G subclasses were measured in 32 cystic fibrosis (CF) patients, 30 asthmatics and 27 controls. When compared with the asthmatic patients and controls, the CF patients had raised levels of all IgG subclasses as well as total IgG, IgM and IgA, but there was not a statistically significant increase in IgE. The levels of immunoglobulins in the CF patients were examined in relation to the clinical features of the disease. Raised levels of IgG4 were related to levels of IgE, but these raised levels of IgG4 appeared to be part of a general increase in total IgG and not an isolated feature. There was a significant correlation between the total IgG level and its subclasses, IgG1, IgG2, IgG3, IgG4 and IgA. IgG1 was significantly correlated with IgG2 and IgG4; IgG2 with IgG4; and IgG4 with IgE. Total IgG was the immunoglobulin most closely correlated with poor lung function. Serum IgA was higher in patients with positive immediate skin prick reactions to pollens (p less than 0.005) and death within two years of the study was related to high levels of total IgG (p less than 0.01), IgG3 (p less than 0.001), IgA (p less than 0.001), and IgE (p less than 0.005).
对32名囊性纤维化（CF）患者、30名哮喘患者和27名对照者进行了血清免疫球蛋白和免疫球蛋白G亚类水平的检测。与哮喘患者和对照者相比，CF患者的所有IgG亚类以及总IgG、IgM和IgA水平均升高，但IgE水平没有统计学上的显著升高。根据该疾病的临床特征对CF患者的免疫球蛋白水平进行了检查。IgG4水平的升高与IgE水平相关，但这些升高的IgG4水平似乎是总IgG普遍升高的一部分，而非孤立的特征。总IgG水平与其亚类IgG1、IgG2、IgG3、IgG4和IgA之间存在显著相关性。IgG1与IgG2和IgG4显著相关；IgG2与IgG4相关；IgG4与IgE相关。总IgG是与肺功能差最密切相关的免疫球蛋白。对花粉即刻皮肤点刺反应呈阳性的患者血清IgA较高（p<0.005），研究两年内死亡与总IgG（p<0.01）、IgG3（p<0.001）、IgA（p<0.001）和IgE（p<0.005）水平较高有关。
