蛋白质中的复杂结构：功能与进化
Intricate knots in proteins: Function and evolution.
作者信息
Virnau Peter, Mirny Leonid A, Kardar Mehran
机构信息
Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
出版信息
PLoS Comput Biol. 2006 Sep 15;2(9):e122. doi: 10.1371/journal.pcbi.0020122. Epub 2006 Jul 28.
Our investigation of knotted structures in the Protein Data Bank reveals the most complicated knot discovered to date. We suggest that the occurrence of this knot in a human ubiquitin hydrolase might be related to the role of the enzyme in protein degradation. While knots are usually preserved among homologues, we also identify an exception in a transcarbamylase. This allows us to exemplify the function of knots in proteins and to suggest how they may have been created.
我们对蛋白质数据库中打结结构的研究揭示了迄今为止发现的最复杂的结。我们认为，这种结出现在一种人类泛素水解酶中可能与该酶在蛋白质降解中的作用有关。虽然结通常在同源物中得以保留，但我们也在一种转氨甲酰酶中发现了一个例外。这使我们能够例证蛋白质中结的功能，并推测它们可能是如何形成的。
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