人类糖原基因克隆：聚焦于β3-糖基转移酶和β4-糖基转移酶家族。

Human glycogene cloning: focus on beta 3-glycosyltransferase and beta 4-glycosyltransferase families.

作者信息

Narimatsu Hisashi

机构信息

Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory, Central 2, Umezono 1-1-1, Tsukuba, Ibaraki 305-8568, Japan.

出版信息

Curr Opin Struct Biol. 2006 Oct;16(5):567-75. doi: 10.1016/j.sbi.2006.09.001. Epub 2006 Sep 18.

DOI:10.1016/j.sbi.2006.09.001

PMID:16979334

Abstract

Glycogenes encode proteins involved in glycan synthesis, such as glycosyltransferases, sulfotransferases and sugar-nucleotide transporters. The comprehensive identification and functional analysis of human glycogenes has been ongoing for some time. During the past 20 years, 183 human glycogenes have been cloned and their substrate specificities analyzed. All current information on these human glycogenes and their links with orthologous genes in other species is summarized in the GlycoGene database. In recent years, two glycogene families, beta3-glycosyltransferases and beta4-glycosyltransferases, have been identified and analyzed in particular detail.

摘要

糖原基因编码参与聚糖合成的蛋白质，如糖基转移酶、磺基转移酶和糖核苷酸转运蛋白。对人类糖原基因的全面鉴定和功能分析已经进行了一段时间。在过去20年里，183个人类糖原基因已被克隆，并对其底物特异性进行了分析。关于这些人类糖原基因及其与其他物种直系同源基因的联系的所有现有信息都汇总在糖原基因数据库中。近年来，两个糖原基因家族，即β3-糖基转移酶和β4-糖基转移酶，已经得到了特别详细的鉴定和分析。