Iseki E, Matsushita M, Kosaka K, Suzuki K, Amano N, Saito A
Department of Psychiatry and Neurology, Yokohama City University School of Medicine, Japan.
Acta Neuropathol. 1990;80(3):227-32. doi: 10.1007/BF00294638.
The distribution and morphology of senile plaques (SPs) in the cerebral cortices and subcortical nuclei of six cases of familial Alzheimer's disease (AD) were examined using the Methenamine-Bodian method and compared with those of sporadic AD cases. SPs were grouped into three types according to their morphology. SP types were generally constant at each anatomical site in all of the cases. The SPs of familial cases, however, had a greater tendency to fuse together than those of sporadic cases, especially in the cingulate cortex, presubiculum and striatum. This tendency was more evident in cases with severe amyloid angiopathy. Here it appeared that a SP type corresponding to "diffuse plaques", at least in part, might be formed by transformation from another type. In the globus pallidus, all the familial cases had many compact-like plaques which appeared to be derived from "drusige Entartung" of the capillaries. Furthermore, the regional proportion of two types of SPs occurring in this nucleus varied along its anteroposterior axis. These findings may be the histological hallmarks of atypical AD rather than familial AD.
采用六胺银-博迪安法检查了6例家族性阿尔茨海默病（AD）患者大脑皮质和皮质下核中老年斑（SPs）的分布和形态，并与散发性AD病例进行了比较。根据形态将SPs分为三种类型。在所有病例中，SP类型在每个解剖部位通常是恒定的。然而，家族性病例的SPs比散发性病例更容易融合在一起，尤其是在扣带回皮质、前扣带回和纹状体。在严重淀粉样血管病的病例中，这种趋势更为明显。在这里，至少部分对应于“弥漫性斑块”的SP类型似乎可能是由另一种类型转变而来的。在苍白球中，所有家族性病例都有许多紧密样斑块，这些斑块似乎源自毛细血管的“drusige Entartung”。此外，该核中出现的两种类型SPs的区域比例沿其前后轴变化。这些发现可能是非典型AD而非家族性AD的组织学特征。
