Iseki E, Matsushita M, Kosaka K, Kondo H, Ishii T, Amano N
Department of Psychiatry and Neurology, Yokohama City University School of Medicine, Japan.
Acta Neuropathol. 1989;78(2):131-6. doi: 10.1007/BF00688200.
The morphology, incidence and distribution of senile plaques in the brain stem were examined in 15 cases of Alzheimer's disease, using mainly the Methenamine-Bodian method. The plaques were found in all cases and were grouped into three types according to their morphology. They were not randomly scattered in the brain stem, but had a distribution common to all cases. There were numerous plaques in the periaqueductal gray, superior colliculus, fourth-ventricle floor and superior central nucleus. The plaques were also found less abundantly in the reticular formation, substantia nigra, pontine nucleus and inferior olivary nucleus. There was a tendency for certain plaque types to be associated with specific regions. In the familial cases, the plaques tended to occur even in the regions where they were rare in other cases. The capillaries with plaque-like degeneration were observed not infrequently in the brain stem. The distribution of plaques did not always coincide with that of neurofibrillary tangles.
采用六亚甲基四胺 - 博迪安法，对15例阿尔茨海默病患者脑干中淀粉样斑块的形态、发生率和分布进行了检查。所有病例均发现有斑块，根据其形态可分为三种类型。它们并非随机散布于脑干，而是所有病例都有共同的分布。导水管周围灰质、上丘、第四脑室底部和中央上核有大量斑块。在网状结构、黑质、脑桥核和下橄榄核中也较少发现斑块。某些斑块类型有与特定区域相关的倾向。在家族性病例中，即使在其他病例中斑块较少出现的区域也有斑块倾向。在脑干中经常观察到有斑块样变性的毛细血管。斑块的分布并不总是与神经原纤维缠结的分布一致。
