Mondragón Verónica, Franco Bernardo, Jonas Kristina, Suzuki Kazushi, Romeo Tony, Melefors Ojar, Georgellis Dimitris
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 México D.F., México.
J Bacteriol. 2006 Dec;188(23):8303-6. doi: 10.1128/JB.01052-06. Epub 2006 Sep 15.
The barA and uvrY genes of Escherichia coli encode a two-component sensor kinase and a response regulator, respectively. Although this system plays a major role in the regulation of central carbon metabolism, motility, and biofilm formation by controlling the expression of the CsrB and CsrC noncoding RNAs, the environmental conditions and the physiological signal(s) to which it responds remain obscure. In this study, we explored the effect of external pH on the activity of BarA/UvrY. Our results indicate that a pH lower than 5.5 provides an environment that does not allow activation of the BarA/UvrY signaling pathway.
大肠杆菌的barA和uvrY基因分别编码一种双组分传感激酶和一种响应调节因子。尽管该系统通过控制CsrB和CsrC非编码RNA的表达在中心碳代谢、运动性和生物膜形成的调节中起主要作用，但其响应的环境条件和生理信号仍不清楚。在本研究中，我们探究了外部pH对BarA/UvrY活性的影响。我们的结果表明，低于5.5的pH提供了一个不允许BarA/UvrY信号通路激活的环境。
